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Infusion therapies are a fast and effective way to provide the necessary nutrients, antioxidants, vitamins, immunostimulators and more molecules, thus restoring the balance in the cells, maintaining their proper hydration and removing toxins accumulated in the body.
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INTRAVENOUS THERAPIES WITH THE PURPOSE OF REGENERATION
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Nicotinamide dinucleotide (NAD+) is present in all living cells and plays a central role in many biological reactions. Its role as a cofactor in glycolysis and the Krebs cycle - the processes providing cellular energy - is well known. NAD+ plays a key role in cellular metabolism and is a co-substrate for enzymes that play a key role in processes that affect the rate of aging. Aging is characterized by disruption of homeostasis, impaired recovery, reduced regenerative capacity and accumulation of damage at the cellular level, which lead to various pathological processes in the body. The main changes occurring with aging and possible interventions are shown in the following table.
The hallmarks of aging are key cellular changes that underlie the cascade of events that lead to systemic age-related decline |
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A hallmark of aging |
Role of NAD+ |
References |
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Genomic instability |
Adequate NAD+ availability is critical for driving DNA repair enzymes and pathways such as PARP1, SIRT1 and SIRT6 |
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Cellular aging |
Low NAD+ promotes skin aging, while restoring NAD+ reduces the burden of aging cells |
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Epigenetic changes |
NAD+-dependent sirtuins are critical for juvenile epigenetic regulation. Reduced NAD+ means that sirtuins cannot perform this critical role |
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Mitochondrial dysfunction |
Adequate NAD+ is critical for healthy mitochondrial function and for the removal of damaged mitochondria |
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Deletion of telomeres |
Replenishment of NAD+ has been found to alleviate telomere dysfunction |
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Altered intracellular communication |
Low NAD+ promotes age-related inflammation |
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Loss of proteostasis |
NAD+ is required for SIRT1-mediated activation of autophagy to clear damaged cellular proteins |
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Deregulated nutrient reporting |
Nivatand of NAD+ are critical for sensing the energy status of the cell to adapt to energy stress |
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Depletion of stem cells |
Replenishment of NAD+ leads to stem cell rejuvenation |
NAD+ has been identified as a key metabolic intermediate associated with many of the hallmarks of aging.
One of the possible interventions is the replacement of NAD+ levels that decrease with age, which leads to the activation of autophagy, which clears damaged proteins, ensures efficient regeneration and methylation of DNA, activates own stem cells, removes dysfunctional mitochondria. Of course, simply maintaining NAD+ at optimal levels is not enough to slow the rate of aging. A complex approach is necessary, including substances that increase the production of nitric oxide, on which the elasticity of the vascular walls depends, antioxidants such as alpha lipoic acid, and also resveratrol. Resveratrol has antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective and cardiovascular protective effects, therefore it can protect against various chronic diseases, such as cardiovascular disease (CVD), cancer, liver disease, obesity, diabetes, disease of Alzheimer's and Parkinson's disease.
In addition, combinations of amino acids and vitamins, which we do not get in sufficient quantities from food, are applied as telomerase activators, which leads to the restoration of the length of telomeres - end sections of chromosomes and the main sign of the actual age of the organism. Telomerase activators in combination with NAD+ are at the heart of epigenetic reprogramming of cells leading to cellular rejuvenation.
Stem cells
Stem cells can improve and cure chronic diseases, degenerative diseases, slow the rate of aging and much more. It is a pool of non-specialized (reserve) cells that every organism has, and these non-specialized cells can, under certain conditions, "specialize" and replace almost every type of cell in the body. Unlike injecting stem cells locally to locally heal or affect a tissue or organ, intravenously administered stem cells reach all organs of the body. The potential of this innovative application is almost limitless. Stem cells can achieve new cell growth and regeneration when the body's normal mechanisms fail or are exhausted. Stem cells, under appropriate stimulation, continue to divide, grow and produce additional stem cells or can become specialized cells that continue to promote cell regeneration in the body.